Salicylates and Nocturia?

When I experimented with intentionally eating lots of foods high in naturally occurring salicylic acid, the clearest issue that happened was needing to urinate frequently overnight, up to six times during eight hours of sleep.

Is there any research about this?

A brief search turned up conflicting information. (Aspirin is acetylsalicylic acid).

Aspirin side effect: Nocturia


J. Le Fanu, The value of aspirin in controlling the symptoms of nocturnal polyuria

Housekeeping Tips for Environmental Allergens

This started for my spouse’s dermatographism after testing positive to almost all environmental triggers (dust mite, pollen, mold, cat and dog, etc.). This may all be due to mast cell activation syndrome (MCAS). In real life my partner reacts to dust mite, some pollens, cats, and possibly mold.

No fragrance (soaps, shampoos, laundry detergent, lotion, cosmetics, etc.).

No harsh cleaners (vinegar, baking soda suffice for most jobs).

Hot wash and dry all sheets, pillow covers, blanket covers, etc. at least once every two weeks. Dust mite reproduce in a month.

Use a dust mite proof mattress cover.

On a side note, it may actually help to NOT make your bed. Dust mite thrive in moist, warm environments. Expose your bed to the cool and dry air. Hang blanket over headboard or something if possible.

No carpets, if possible.

Vacuum frequently (at least once a week) with a model that has hepa filters.

Ventilate. Ventilate. Ventilate. Keep everything dry.

Keep an eye out for any spots that tends to hold moisture for mold growth.

Treat with vinegar at first sight of any mold.

Be very careful about using chemical insecticide, try to find alternatives. Diatomaceous earth maybe?

Dermatographic Urticaria

What is it?

Also called “skin writing”, where friction (scratching or some other contact) causes red hives or raised skin.


Likely an overabundance of histamine in the body. Some possibilities might be mast cell activation syndrome (MCAS), environmental allergens, mild chronic food issues, high histamine foods, histamine releasing foods, or body does not break down histamine well due to lack of enzymes such as diamine oxidase?

Ways to control?

Aside from antihistamines, our allergist at the time recommended better control of environmental factors such as dust mite control and removing fragrance. Also to avoid tomatoes and berries (histamine releasing foods?).

What happened?

My partner’s dermatographism disappeared along with our diet experiments but at the same time we started better management for environmental allergens as well, so it is not clear what was the main culprit. Regardless this didn’t come back except for a brief return during travel when we had much more fermented foods and was in a dusty environment. So again, not sure which is the cause, or perhaps it is both.

Insecticide Incident

Several years ago we almost killed ourselves trying to rid our home of ants. Of course this is a slight exaggeration, but our health issues flared for nearly a year after spraying our kitchen and ultimately led us down the path of diet experiments. We now know better than to turn to chemicals first.

Between the two of us, a couple of issues that seemed to be linked to the insecticide was extremely heavy periods that lasted nearly a year and hives covering the whole body that just wouldn’t go away for weeks even with antihistamines. It only calmed down later doctor prescribed prednisone (steroid).

This reminded me of my aversion to bug repellent or mosquito killers as far back as I can remember. Family used to tease me that I was a bug in a past life. Does salicylate (as nature’s pesticide/ insecticide) sensitivity or multiple chemical sensitivity have a connection to repulsion toward strong scents and insecticides?

Questions from Celiac Disease

Wheat/ gluten is the best studied, but for other foods how can you know if you might actually have an autoimmune issue like celiac disease and not an allergy?

This matters because, if one has an autoimmune disease like celiac, even if there are no noticeable symptoms (silent celiac), you must strictly avoid. Whereas the guidelines for allergies might be to eat at your tolerance level so that you can gradually desensitize.

What if, even below the threshold for symptoms one is causing harm to oneself as in the case of celiac? What if we just don’t know that yet for other foods?

For allergies there is also the possibility of outgrowing the sensitivity so it is recommended to periodically test tolerance, whereas for celiac disease you need to avoid for life.

Thoughts on Gluten Cross Reactive Foods

After coming across many blogs talking about “19 gluten cross reactive foods” I was first concerned and worried, then overwhelmed by the sheer number of foods that may be problematic.

Then I found another busting the “myth” (Christina Graves), doing a better job of it than I ever could, and clearing up the confusion. This also prompted me to finally read at least the abstract and conclusion of the original study (Aristo Vojdani, Igal Tarash Cross-Reaction between Gliadin and Different Food and Tissue Antigens, Food and Nutrition Sciences, Vol.4 No.1, January 2013). The 19 foods were the initial suspects, so to speak, but among them only milk, corn, rice, and also millet and yeast (but these possibly due to cross contamination) were found to possibly cause issues. Also the study was done for cross reactivity with α-gliadin, relevant for celiac disease.

Had I gone to the source from the beginning, I would have known that this probably doesn’t apply to me to begin with. As far as I know I am not celiac. I am most likely reacting to ω-gliadin (based on the fact that my symptoms are exacerbated by exercise), another component of gluten. And those are not the only two parts that make up the structure of gluten! NCGS (non-celiac gluten sensitivity) might involve other parts.

Along with gluten, I too have problems with milk (confirmed allergy) and fresh yeast. Does it mean anything that it partially matches the study’s results?
Among the 19 suspects, I have problems with quinoa, buckwheat (confirmed allergy), and amaranth.
But are these cross reactions to gluten? More likely they are separate problems of their own or cross reactions to my other allergies.

As I too started my food journey by going gluten free, it was all too easy to think that I was either being “glutened” or was having gluten cross reactions when I continued to have symptoms. At least for me, the answer turned out to be additional allergies and sensitivities apart from gluten. This is also mentioned in the original study’s conclusion.

“If after adherence to a strict gluten-free diet and the elimination of cross-reactive foods symptoms still persist, further investigation for other food intolerances should follow.”

Yet again, cross reactivity is a complicated issue, at the molecular level. While it can  indicates increased possibility, it may or may not apply to you. Depends on how your immune system identifies the “offenders” and how accurate it is. So, individual answers may all be different.

Following such lists can be misleading, inconvenient, possibly dangerous without first testing yourself.

Regarding testing, along with formal skin tests, blood tests, or even endoscopies, carefully done elimination diets, food challenges, and possibly data tracking and molecular structure simulations might help find answers.

On the State of Stool

In my experience as someone with multiple allergies and sensitivities, if I don’t have ideal stool, it’s highly likely I am reacting to something and causing irritation, inflammation, and even bleeding in the bowels.

When I eat only my safe foods, the bathroom trip couldn’t be anymore pleasant. It is quick, painless, no urgency, and so clean. Seriously, now that I know this is possible for me, I pay more attention to when things start to deviate from the ideal.

What is ideal? Soft banana shaped stool that comes out clean, like no wiping necessary. Ever had pets or experience with livestock? One pretty clear sign of health is they have clean behinds.

Non ideal situations include constipation, diarrhea, or bloody stool, obviously. But also black or tarry (signs of internal bleeding), messy, sticky, oily or floating, or stool with no form along with a bleeding or irritated anus.

Allergies Running in Families

It is highly likely you share allergic, sensitive tendencies with members of your family. Everyone else in my immediate family has at least one food allergy and some have seasonal allergies as well, and at least one person has atopic dermatitis. I thought I was the lucky one without any food issues whatsoever, even though I was also the one most frequently in and out of the hospital.

Well, once we caught gluten, turns out I have many. And everyone else in the family also react to gluten to various degrees but no one knew so far! One person told me that for the first time in their life they are not aware of their insides, they always had some pain, and for the first time they had stool that actually had a shape! Also tinnitus (ringing in ears) disappeared and eye fatigue reduced. Another told me their severe insomnia and daily muscle cramps and restless legs syndrome greatly reduced. Another is shy about the details but felt enough difference that they eat mostly gluten free on their own. All of them also get noticeable bloating and gas when they do eat wheat.

Some studies show Neanderthal genes are to blame for allergies.

Rethinking the Cost Benefit Analysis

The allergist’s goal is to expand the patient’s diet as much as possible. Unnecessarily limiting one’s diet is too big of a cost, too difficult to maintain. The social cost is too big. And potential gaps in nutrition is worrisome. 

Arguments along these lines are used to caution against restricting one’s diet. And I used to agree with it all.

But now that I’ve experienced firsthand what a difference removing my problem foods made, I argue there are costs associated with not finding and following the diet right for you.

Pills for symptom control, constant inflammation, and potentially lasting brain damage for migraine sufferers, are just a few.

What really is the higher cost here?

Can we afford to not find the true cause?

Besides we in modern developed countries have access to a wider variety of foods than much of our ancestors or even many less developed areas in the present day, even if you have multiple allergies to contend with. So much so that people can afford to limit their diet based on personal values and beliefs.

Despite occasionally tiresome limits and caution needed with my diet, my quality of life has vastly improved. Much higher energy levels, not having to feel chronically sick in both mind and body, being able to enjoy exercise, etc. Isn’t being able to use and enjoy our mind and body to the best of its potential what life is all about?

People are Over-diagnosing Themselves?!

Every now and then a catchy title circulates “most adults who claim food allergies are not allergic!” or “millions of Americans not food allergic as they claim”.

This makes it sound like many are faking their illnesses.

First of all, if you actually read these studies, the percentage of people who actually do have food allergies are quite high. So you could have made the title “majority of adults who claim food allergies are actually allergic” or “millions of Americans food allergic” or “food allergy in adults are on the rise”, which would have all been closer to the truth. But maybe not quite as clickable or joke-worthy.

Dismissing them as faking it, being hypochondriacs, stupid or mental helps no one.

Then what are the possibilities? What might actually be happening?

1. False negative. They actually do have an allergy but it did not show up in testing.

2. Non-IGE mediated allergy. Some of these can be severe, like FPIES.

3. Autoimmune disorder, like celiac disease.

4. Gastrointestinal allergy. Can be both IGE or non-IGE mediated and most don’t show up on skin tests.

5. Food intolerance. Not an allergy, not immediately life threatening, but can still cause a lot of havoc.

6. Wrong culprit. They have a food issue, but to a different food.

7. Outgrew the allergy. They had the allergy but outgrew it by the time testing was done. Actually a happy ending!