Non-IgE mediated allergies are a very large and understudied area. And very real. It is possibly the culprit in many long suffering people.
Lots of things are not known well enough especially to the general public, even to practicing doctors.
Makes me wonder how many others suffer from “hidden” allergies and sensitivities.
Especially those prone to gastrointestinal problems, headaches, joint pain, chronic fatigue syndrome, mysterious idiosyncratic inflammations, autoimmunity, and also some mental health issues.
All the underlying mechanisms are not defined well enough that there are no simple medical tests. The skin prick test can detect just a small subset of allergic disorders, doesn’t even detect all the IgE mediated cases.
Trigger and symptom tracking assisted by data might be a viable alternative until better diagnostic methods are developed. A good tracking program can also guide and assist elimination diets.